Functional connectivity density alterations in schizophrenia

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Functional connectivity density alterations in schizophrenia

BACKGROUND Schizophrenia is characterized by altered resting-state functional connectivity. Most previous studies have focused on changes in connectivity strengths; however, the alterations in connectivity density in schizophrenia remain largely unknown. Here, we aimed to investigate changes in resting-state functional connectivity density (rsFCD) in schizophrenia. METHODS A total of 95 schiz...

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Introduction: Medial temporal sclerosis (MTS) is a form of mesial temporal lobe epilepsy (mTLE). It is typically characterized by structural alterations in hippocampus (HC) and related mesial temporal lobe (MTL) network. Resting state functional connectivity (RSFC) is considered an ideal technique in quantifying the dysfunction and maladaptation in MTL network. It is well- dem...

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The first functional neuroimaging studies of schizophrenia, using single photon (SPET) and positron emission tomography (PET), led to the notion of abnormal 'hypofrontality' (Ingvar & Franzen, 1974). Although consistent with data linking schizophrenia with deficits in frontal function, the popularity of'hypofrontality' gradually faded as technically and methodologically more sophisticated studi...

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Functional connectivity density mapping.

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ژورنال

عنوان ژورنال: Frontiers in Behavioral Neuroscience

سال: 2014

ISSN: 1662-5153

DOI: 10.3389/fnbeh.2014.00404